5-Amino-1MQ

5-Amino-1MQ (5-amino-1-methylquinolinium) blocks an enzyme called NNMT (nicotinamide N-methyltransferase) that is highly active in fat tissue. In laboratory and rodent studies, inhibiting NNMT increased the energy fat cells burn and reduced fat accumulation.

The rationale ties into the NAD+ and methylation systems: NNMT consumes nicotinamide (a building block the cell uses to regenerate NAD+) and a methyl donor called SAM. Blocking it is thought to spare those pools and nudge fat-cell metabolism toward higher energy expenditure.

Importantly, the evidence is preclinical — cell cultures and diet-induced-obesity mouse models. There are no published human trials, no established human dosing or safety data, and it is supplied strictly for laboratory research, not human use.