Appears endogenously and is widely studied in vitro for skin remodeling; topical cosmetic use is common, systemic therapeutic claims are not established by controlled trials.
GHK-Cu is a tiny three-amino-acid peptide that occurs naturally in the body and binds copper. It's best understood as a signaling and copper-delivery molecule for skin and connective tissue.
In laboratory and skin studies it switches on a broad set of genes involved in rebuilding the extracellular matrix — boosting collagen and elastin production, supporting new blood-vessel growth, and activating antioxidant and wound-healing programs. This is the basis for its widespread use in topical skincare.
The evidence is strongest for those in-vitro and topical cosmetic effects. Claims of systemic, whole-body therapeutic benefit are not established by controlled human trials, so it's best viewed as a well-supported cosmetic ingredient with unproven systemic uses.
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