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GH Fragment

HGH Fragment 176-191

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Overview

The lipolytic C-terminal region of growth hormone; the related modified version (AOD-9604) failed pivotal human obesity trials.

How it works

HGH Fragment 176-191 is the segment of the growth-hormone molecule associated with fat metabolism — it's essentially the parent of AOD-9604.

The concept is the same: stimulate fat breakdown and limit fat storage while leaving growth hormone's blood-sugar and IGF-1 effects out of the picture.

And the reality is similar too: human evidence for meaningful fat loss is weak and unconvincing, and it is not an approved treatment.

Mechanism · Detailed Analysis
Molecular targetThe GH(176-191) lipolytic fragment — the parent sequence of AOD-9604.
Proposed downstream effectsProposed lipolysis and anti-lipogenesis independent of IGF-1.
Evidence & caveatsHuman evidence for fat loss is weak and unconvincing.
Published EvidenceLoading cited studies from PubMed…
Human Data ···

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Animal ···

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In Vitro ···

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Educational aggregation of public literature. Not medical advice and not a recommendation to use any compound. Many compounds here are not approved for human use. Consult a licensed clinician.