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Growth-Hormone Secretagogue

Ipamorelin

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Overview

A ghrelin-receptor agonist with relatively selective GH release in early studies; development did not yield an approved product.

How it works

Ipamorelin is an injectable peptide that, like MK-677, works by activating the ghrelin receptor (GHS-R1a) to prompt growth-hormone release.

Its defining feature is selectivity: in early studies it produced clean GH pulses with little effect on stress hormones like cortisol or on prolactin — distinguishing it from older, 'messier' growth-hormone-releasing peptides. That cleaner profile is the main reason it's popular in research and gray-market contexts.

It's short-acting, so it produces brief pulses rather than sustained elevation, and it was only ever studied in early-phase work. It is not an approved therapy.

Mechanism · Detailed Analysis
Molecular targetA selective agonist of the ghrelin receptor GHS-R1a.
Signaling & downstream effectsProduces GH pulses with minimal effect on ACTH/cortisol or prolactin in early studies — more selective than first-generation GHRPs.
PharmacokineticsShort-acting, yielding transient GH pulses.
CaveatsStudied only in early-phase work; not an approved therapy.
Published EvidenceLoading cited studies from PubMed…
Human Data ···

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Animal ···

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In Vitro ···

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Educational aggregation of public literature. Not medical advice and not a recommendation to use any compound. Many compounds here are not approved for human use. Consult a licensed clinician.