Neuroprotective Compound

J-147

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Overview

A synthetic curcumin derivative with neuroprotective effects in Alzheimer’s mouse models; no human data.

How it works

J-147 is a synthetic derivative of curcumin (the active compound in turmeric), engineered to be more potent and brain-active, and studied for Alzheimer's disease.

Its identified molecular target is a mitochondrial enzyme (ATP synthase), and through that and related stress pathways it reduced markers of brain aging and neurodegeneration in mouse models.

All of this is preclinical — there's no human efficacy data — so it's an interesting research candidate rather than anything proven in people.

Mechanism · Detailed Analysis

Molecular targetA synthetic curcumin derivative that binds mitochondrial ATP synthase and modulates related stress pathways.

Proposed downstream effectsReduced age-associated neurodegeneration markers in Alzheimer’s mouse models.

Evidence & caveatsEntirely preclinical.

Published EvidenceFree · cited live from PubMed

Human Data 22

Study

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

Sanchez KL et al. · International journal of molecular sciences · 2025 — PMID 40243519 ↗

Research Support, Non-U.S. Gov't

J147 affects cognition and anxiety after surgery in Zucker rats

Oberman K et al. · Physiology & behavior · 2024 — PMID 37989448 ↗

Review

The search for anti-oxytotic/ferroptotic compounds in the plant world

Soriano-Castell D et al. · British journal of pharmacology · 2021 — PMID 33931859 ↗

Review

Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review

Qiu F et al. · BMC neurology · 2023 — PMID 37674139 ↗

Review

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Maher P et al. · Cell chemical biology · 2020 — PMID 33176157 ↗

Review

ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis

Ebanks B et al. · Aging · 2020 — PMID 32853175 ↗

Research Support, N.I.H., Extramural

Elevating acetyl-CoA levels reduces aspects of brain aging

Currais A et al. · eLife · 2019 — PMID 31742554 ↗

Study

A novel curcumin derivative for the treatment of diabetic neuropathy

Daugherty DJ et al. · Neuropharmacology · 2018 — PMID 29122628 ↗

Research Support, Non-U.S. Gov't

Metabolism of a potent neuroprotective hydrazide

Chiruta C et al. · Bioorganic & medicinal chemistry · 2013 — PMID 23582448 ↗

Research Support, N.I.H., Extramural

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

Currais A et al. · Aging · 2015 — PMID 26564964 ↗

Study

In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase

Emmanuel IA et al. · Current pharmaceutical biotechnology · 2020 — PMID 32598251 ↗

Study

ATP Synthase, a Target for Dementia and Aging?

Larrick JW et al. · Rejuvenation research · 2018 — PMID 29461942 ↗

See all 22 on PubMed →

Animal 11

Research Support, Non-U.S. Gov't

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

He L et al. · Biochemical and biophysical research communications · 2025 — PMID 40712391 ↗

Review

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Liang Z et al. · Pharmacology & therapeutics · 2021 — PMID 33227325 ↗

Research Support, N.I.H., Extramural

Geroprotective effects of Alzheimer's disease drug candidates

Kepchia D et al. · Aging · 2021 — PMID 33550278 ↗

Research Support, Non-U.S. Gov't

Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT(1A) receptor

Lian L et al. · Neuropharmacology · 2018 — PMID 29626566 ↗

Study

J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway

Qiu F et al. · Journal of molecular histology · 2023 — PMID 37676534 ↗

Research Support, Non-U.S. Gov't

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Chen HY et al. · Journal of molecular neuroscience : MN · 2015 — PMID 25982925 ↗

Research Support, N.I.H., Extramural

J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway

Jin R et al. · Translational research : the journal of laboratory and clinical medicine · 2024 — PMID 39245209 ↗

Research Support, Non-U.S. Gov't

Activation of monoaminergic system contributes to the antidepressant- and anxiolytic-like effects of J147

In Vitro 8

Research Support, Non-U.S. Gov't

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

He L et al. · Biochemical and biophysical research communications · 2025 — PMID 40712391 ↗

Study

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

Sanchez KL et al. · International journal of molecular sciences · 2025 — PMID 40243519 ↗

Study

J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox(™) Safety and Genotoxicity Analysis

Lapchak PA et al. · Journal of neurology & neurophysiology · 2013 — PMID 25364619 ↗

Research Support, Non-U.S. Gov't

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Chen HY et al. · Journal of molecular neuroscience : MN · 2015 — PMID 25982925 ↗

Study

Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT(1A)-Mediated cAMP Signaling

Li J et al. · Frontiers in neuroscience · 2020 — PMID 32733195 ↗

Evaluation Study

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1

Lv J et al. · Acta cirurgica brasileira · 2018 — PMID 30020315 ↗

Study

The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

Lv J et al. · Frontiers in pharmacology · 2021 — PMID 34887767 ↗

Study

ATP synthase is a promising target for identifying activated and non-activated adipose tissues

Jie CVML et al. · Nature communications · 2026 —

Studies are surfaced live from the U.S. National Library of Medicine (PubMed). biohackr indexes and links the published record; it does not host or alter source articles.

Published EvidenceLoading cited studies from PubMed…

Human Data ···

Searching the published record…

Animal ···

Searching the published record…

In Vitro ···

Searching the published record…

Educational aggregation of public literature. Not medical advice and not a recommendation to use any compound. Many compounds here are not approved for human use. Consult a licensed clinician.

Published EvidenceFree · cited live from PubMed

Human Data 22

Study

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

Sanchez KL et al. · International journal of molecular sciences · 2025 — PMID 40243519 ↗

Research Support, Non-U.S. Gov't

J147 affects cognition and anxiety after surgery in Zucker rats

Oberman K et al. · Physiology & behavior · 2024 — PMID 37989448 ↗

Review

The search for anti-oxytotic/ferroptotic compounds in the plant world

Soriano-Castell D et al. · British journal of pharmacology · 2021 — PMID 33931859 ↗

Review

Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review

Qiu F et al. · BMC neurology · 2023 — PMID 37674139 ↗

Review

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Maher P et al. · Cell chemical biology · 2020 — PMID 33176157 ↗

Review

ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis

Ebanks B et al. · Aging · 2020 — PMID 32853175 ↗

Research Support, N.I.H., Extramural

Elevating acetyl-CoA levels reduces aspects of brain aging

Currais A et al. · eLife · 2019 — PMID 31742554 ↗

Study

A novel curcumin derivative for the treatment of diabetic neuropathy

Daugherty DJ et al. · Neuropharmacology · 2018 — PMID 29122628 ↗

Research Support, Non-U.S. Gov't

Metabolism of a potent neuroprotective hydrazide

Chiruta C et al. · Bioorganic & medicinal chemistry · 2013 — PMID 23582448 ↗

Research Support, N.I.H., Extramural

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

Currais A et al. · Aging · 2015 — PMID 26564964 ↗

Study

In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase

Emmanuel IA et al. · Current pharmaceutical biotechnology · 2020 — PMID 32598251 ↗

Study

ATP Synthase, a Target for Dementia and Aging?

Larrick JW et al. · Rejuvenation research · 2018 — PMID 29461942 ↗

See all 22 on PubMed →

Animal 11

Research Support, Non-U.S. Gov't

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

He L et al. · Biochemical and biophysical research communications · 2025 — PMID 40712391 ↗

Review

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Liang Z et al. · Pharmacology & therapeutics · 2021 — PMID 33227325 ↗

Research Support, N.I.H., Extramural

Geroprotective effects of Alzheimer's disease drug candidates

Kepchia D et al. · Aging · 2021 — PMID 33550278 ↗

Research Support, Non-U.S. Gov't

Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT(1A) receptor

Lian L et al. · Neuropharmacology · 2018 — PMID 29626566 ↗

Study

J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway

Qiu F et al. · Journal of molecular histology · 2023 — PMID 37676534 ↗

Research Support, Non-U.S. Gov't

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Chen HY et al. · Journal of molecular neuroscience : MN · 2015 — PMID 25982925 ↗

Research Support, N.I.H., Extramural

J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway

Jin R et al. · Translational research : the journal of laboratory and clinical medicine · 2024 — PMID 39245209 ↗

Research Support, Non-U.S. Gov't

Activation of monoaminergic system contributes to the antidepressant- and anxiolytic-like effects of J147

In Vitro 8

Research Support, Non-U.S. Gov't

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

He L et al. · Biochemical and biophysical research communications · 2025 — PMID 40712391 ↗

Study

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

Sanchez KL et al. · International journal of molecular sciences · 2025 — PMID 40243519 ↗

Study

J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox(™) Safety and Genotoxicity Analysis

Lapchak PA et al. · Journal of neurology & neurophysiology · 2013 — PMID 25364619 ↗

Research Support, Non-U.S. Gov't

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Chen HY et al. · Journal of molecular neuroscience : MN · 2015 — PMID 25982925 ↗

Study

Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT(1A)-Mediated cAMP Signaling

Li J et al. · Frontiers in neuroscience · 2020 — PMID 32733195 ↗

Evaluation Study

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1

Lv J et al. · Acta cirurgica brasileira · 2018 — PMID 30020315 ↗

Study

The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

Lv J et al. · Frontiers in pharmacology · 2021 — PMID 34887767 ↗

Study

ATP synthase is a promising target for identifying activated and non-activated adipose tissues

Jie CVML et al. · Nature communications · 2026 —

Studies are surfaced live from the U.S. National Library of Medicine (PubMed). biohackr indexes and links the published record; it does not host or alter source articles.

J-147

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

J147 affects cognition and anxiety after surgery in Zucker rats

The search for anti-oxytotic/ferroptotic compounds in the plant world

Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis

Elevating acetyl-CoA levels reduces aspects of brain aging

A novel curcumin derivative for the treatment of diabetic neuropathy

Metabolism of a potent neuroprotective hydrazide

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase

ATP Synthase, a Target for Dementia and Aging?

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Geroprotective effects of Alzheimer's disease drug candidates

Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT(1A) receptor

J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway

Activation of monoaminergic system contributes to the antidepressant- and anxiolytic-like effects of J147

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox(™) Safety and Genotoxicity Analysis

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT(1A)-Mediated cAMP Signaling

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1

The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

ATP synthase is a promising target for identifying activated and non-activated adipose tissues

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

J147 affects cognition and anxiety after surgery in Zucker rats

The search for anti-oxytotic/ferroptotic compounds in the plant world

Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis

Elevating acetyl-CoA levels reduces aspects of brain aging

A novel curcumin derivative for the treatment of diabetic neuropathy

Metabolism of a potent neuroprotective hydrazide

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase

ATP Synthase, a Target for Dementia and Aging?

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Geroprotective effects of Alzheimer's disease drug candidates

Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT(1A) receptor

J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway

Activation of monoaminergic system contributes to the antidepressant- and anxiolytic-like effects of J147

J147 modulates microglial polarization via CAMKK2/AMPK signaling to ameliorate neuroinflammation

Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox(™) Safety and Genotoxicity Analysis

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT(1A)-Mediated cAMP Signaling

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1

The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation

ATP synthase is a promising target for identifying activated and non-activated adipose tissues

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1

Labeling of a glucose binding protein in the rabbit intestinal brush border membrane

The V-region sequence of the H chain from a third rabbit anti-pneumococcal antibody