LGD-4033

LGD-4033 (ligandrol) is a high-affinity SARM that binds the androgen receptor strongly to stimulate muscle and bone, while aiming to avoid the broader effects of testosterone.

In its short phase-1 study it did increase lean body mass in a dose-dependent way, confirming the anabolic signal.

But even at low doses and over just three weeks, it suppressed the body's own testosterone, SHBG, and HDL cholesterol (these recovered after stopping). It is not an approved drug and is banned in sport — the lean-mass benefit comes bundled with measurable hormonal disruption.