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ERR Agonist (Exercise Mimetic)

SLU-PP-332

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Overview

A pan-ERR agonist showing endurance/metabolic effects in rodents; there is no human data.

How it works

SLU-PP-332 is a recently developed compound nicknamed an 'exercise mimetic.' It activates the estrogen-related receptors (ERRs), which act as master regulators of how cells generate and burn energy.

By switching on ERR, it ramps up the genes for oxidative metabolism and for making new mitochondria in muscle, increasing fat burning and endurance capacity in rodents — effects resembling some of what exercise produces.

The crucial point: this is entirely preclinical. There is no human data at all, and its safety in people is unknown, so any claims about human benefit are speculative.

Mechanism · Detailed Analysis
Molecular targetA pan-agonist of the estrogen-related receptors (ERRα/β/γ).
Signaling & downstream effectsUpregulates oxidative-metabolism and mitochondrial-biogenesis genes in muscle, raising fatty-acid oxidation and endurance ("exercise mimetic") in rodents.
Evidence & caveatsEntirely preclinical; there is no human data and safety is unknown.
Published EvidenceLoading cited studies from PubMed…
Human Data ···

Searching the published record…

Animal ···

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In Vitro ···

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Educational aggregation of public literature. Not medical advice and not a recommendation to use any compound. Many compounds here are not approved for human use. Consult a licensed clinician.