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REV-ERB Agonist

SR-9009

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Overview

A circadian-clock (REV-ERB) agonist with metabolic effects in mice, but very poor oral bioavailability and no human evidence.

How it works

SR-9009 (stenabolic) targets a different system entirely: it activates REV-ERB, a protein that's part of the body's internal clock (circadian system) and also regulates metabolism.

By switching on REV-ERB, it represses certain clock and metabolic genes and increases mitochondrial activity in rodents, producing endurance- and metabolism-related effects in those models.

Two big caveats: it has very poor oral absorption, which undermines the marketed oral products, and there's no human data at all. It's also banned in sport. Much of its 'fat-burner' reputation outruns its actual, mostly-rodent and poorly-absorbed, evidence.

Mechanism · Detailed Analysis
Molecular targetAn agonist of the REV-ERBα/β nuclear receptors, components of the circadian clock.
Signaling & downstream effectsRepresses clock and metabolic target genes (e.g., Bmal1) and increases mitochondrial activity in rodents.
PharmacokineticsVery poor oral bioavailability — which undermines the pharmacology of marketed oral products.
CaveatsNo human data; banned in sport.
Published EvidenceLoading cited studies from PubMed…
Human Data ···

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Animal ···

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In Vitro ···

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Educational aggregation of public literature. Not medical advice and not a recommendation to use any compound. Many compounds here are not approved for human use. Consult a licensed clinician.