Tesamorelin

Tesamorelin is a stabilized copy of growth-hormone-releasing hormone (GHRH), the brain signal that tells the pituitary to release growth hormone. Rather than injecting growth hormone directly, it nudges your own pituitary to put out GH in its natural, pulsing rhythm.

Because it works one step upstream — through the body's own feedback loops — the resulting rise in GH and its downstream messenger IGF-1 is more physiologic than giving GH itself. The clinically useful consequence is a selective reduction in visceral (deep abdominal) fat, which is why it's approved specifically for the abnormal fat accumulation seen in HIV-associated lipodystrophy.

A chemical modification protects it from rapid breakdown, but it's still injected daily. Because it raises IGF-1, that level is monitored during use, and it's avoided where boosting GH/IGF-1 would be risky, such as active cancer.